Transcribed letters between Dr. Ralph N. Isham, his father Nelson Isham, brother Charles Isham, and son George S. Isham mostly pertaining to the home and estate of Nelson Isham. Also photographs of Ralph N. Isham and other Isham family members, and a few mementos.

Primarily letters of the Waller family, a wealthy, large, educated family from Kentucky, and later Chicago, pertaining mainly to matters of family activity, family devotion to one another, and especially health. Also included are a family genealogy, biography, and letters from Henry Clay and P.G.T. Beauregard. Related family: Alexander